Oscillatory network markers of subcallosal cingulate deep brain stimulation for depression

• DOI: 10.1016/j.brs.2023.11.016
• Publication Date: 2023-12-06T04:20:38Z
• Authors: M. Scherer; I.E. Harmsen; N. Samuel; G.J.B. Elias; J. Germann; A. Boutet; C.E. MacLeod; P. Giacobbe; N.C. Rowland; A.M. Lozano; L. Milosevic
• Keywords: Magnetoencephalography; Brain stimulation; Treatment-Resistant Depression; Depression

Identifying functional biomarkers related to treatment success can aid in expediting therapy optimization, as well contribute a better understanding of the neural mechanisms treatment-resistant depression (TRD) and subcallosal cingulate deep brain stimulation (SCC-DBS).Magnetoencephalography data were obtained from 16 individuals with SCC-DBS for TRD 25 healthy subjects. The first objective study was identify region-specific oscillatory modulations that both (i) discriminate (with OFF) controls, (ii) responders non-responders ON). second this work further explore effects intensity frequency on activity identified regions interest.Oscillatory power analyses led identification differentiated based increased alpha (8–12 Hz) decreased gamma (32–116 within nodes default mode, central executive, somatomotor networks, Broca's area, lingual gyrus. Within these nodes, it also found low had stronger modulation than intensity.The network implicate TRD-related involved emotional control/processing, motor control, interaction between speech, vision, memory, which have all been implicated depression. These electrophysiological potential be used proxies optimization. Additional parameter revealed strengthened by increasing or reducing frequency, may represent avenues direction non-responders.