Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson's disease

• DOI: 10.1016/j.brs.2024.04.006
• Publication Date: 2024-04-17T00:16:37Z
• Authors: Chien-Hung Yeh; Yifan Xu; Wenbin Shi; James J. Fitzgerald; Alexander L. Green; Petra Fischer; Huiling Tan; Ashwini Oswal
• Keywords: Subthalamic Nucleus; Local field potential; Neurophysiology

BackgroundGait impairment has a major impact on quality of life in patients with Parkinson's disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15-30 Hz) may contribute to gait impairment, but the precise dynamics this during remain unclear. Additionally, auditory cues are known lead improvements kinematics PD. If neurophysiological mechanisms cueing effect were better understood they could be leveraged treat impairments using adaptive Deep Brain Stimulation (aDBS) technologies.ObjectiveWe aimed characterize subthalamic nucleus (STN) stepping movements PD and establish by which modulate gait.MethodsWe studied STN local field potentials (LFPs) eight while performed movements. Hidden Markov Models (HMMs) used discover transient states spectral occurred without cues.ResultsThe occurrence low high bursts was suppressed after cues. This manifested as decrease their fractional occupancy state lifetimes. Interestingly, α transients showed opposite effect, lifetimes increasing cues.ConclusionsWe show frequency bands differentially modulated gait-promoting These findings suggest enhancement rhythms an approach for ameliorating