Antibacterial and antioxidant activities of compounds isolated from the leaves of Symphonia globulifera (Clusiaceae) and their chemophenetic significance

• DOI: 10.1016/j.bse.2021.104345
• Publication Date: 2021-10-09T02:25:10Z
• Authors: Dénis-Grégoire Téné; Anastasie Ewola Tih; Michael Hermann K...; Rostan Mangoua Talla; Patrick Hervé Bet...; Yanick Kevin Dong...; Carelle Raïssa Dz...; Edwin Mpoh Mmutlane; Derek Tantoh Ndinteh; Bernard Bodo; Raphaël Tih Ghogomu
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Abstract The phytochemical study was done on the methanol extract from of the leaves of Symphonia globulifera. This plant has been used in traditional medicine to treat of different ailments such as malaria, diseases of the skin, diabetes, cough, intestinal worms, pre-hepatic jaundice and fever. Chromatographic fractionation and purification of this extract led to the isolation and characterization of twelve compounds (1–12) including pristriol (1), robustaflavone (2), polycarpol (3), 7''-O-methylrobustaflavone (4), amentoflavone (5), stigmasterol glucoside (6), epicatechin (7), apigenin (8), luteolin (9), 1,5-dihydroxyxanthone (10), β-sitosterol 3-β-D-glucopyranoside (11) and a mixture of stigmasterol and β-sitosterol (12). The structures of compounds 1–12 were elucidated on the basis of 1D and 2D NMR, mass spectrometric and the spectroscopic data as well as comparison with the literature. All these compounds were isolated for the first time from Symphonia genus. The NMR spectra and structure elucidation of compound 1 were reported for the first in the literature. The antibacterial and antioxidant activities of three of these compounds were evaluated. The chemophenetic significance of these compounds is also discussed.