Measurement of resistance-area product by transcranial Doppler: An alternative tool for cognitive screening in hypertensive on drug treatment?

• DOI: 10.1016/j.cccb.2023.100191
• Publication Date: 2023-11-10T10:11:06Z
• Authors: Michel Ferreira M...; Henrique Cotchi S...; Valeria Aparecida...; Ronney B. Panerai; Monica S. Yassuda; Natalia Cristina ...; Claudia Maia Memória; Edson Bor-Seng-Shu; Ricardo Nitrini; Luiz Aparecido Bo...; Ricardo de Carval...
• Keywords: Transcranial Doppler; Montreal Cognitive Assessment; Cognitive Decline

Arterial hypertrophy and remodeling are adaptive responses present in systemic arterial hypertension that can result silent ischemia neurodegeneration, compromising brain connections cognitive performance (CP). However, CP is affected differently over time, so traditional screening methods may become less sensitive assessing certain domains. The study aimed to evaluate whether cerebrovascular hemodynamic parameters serve as a tool for hypertensive without clinically manifest decline. Participants were allocated into groups: non-hypertensive (n=30) [group 1], with systolic blood pressure (SBP) < 140 diastolic (DBP) 90 mmHg (n=54) 2] SBP ≥ or DBP (n=31) 3]. Measurements of middle cerebral artery flow velocity obtained from digital plethysmography transcranial Doppler. For the assessment, Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) broad neuropsychological battery applied. Patients groups 2 3 show no significant differences most clinical-epidemiological variables pulsatility index (p=0.361), however compared group 1 2, patients had greater resistance-area product [RAP] (1.7 [±0.7] vs. 1.2 [±0.2], p<0.001). There was negative correlation between RAP, episodic memory (r = -0.277, p=0.004) processing speed -0.319, p=0.001). RAP reflects real resistance, regardless direct action antihypertensive on microcirculation, seems be potential alternative hypertensive.