The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support

• DOI: 10.1016/j.ccell.2021.01.004
• Publication Date: 2021-01-21T15:37:50Z
• Authors: Anja Irmisch; Ximena Bonilla; Stéphane Chevrier; Kjong-Van Lehmann; Franziska Singer; Nora C. Toussaint; Cinzia Esposito; Julien Mena; Emanuela S. Milani; Ruben Casanova; Daniel J. Stekhoven; Rebekka Wegmann; Francis Jacob; Bettina Sobottka; Sandra Goetze; Jack Kuipers; Jacobo Sarabia de...; Michael Prummer; Mustafa A. Tuncel; Ulrike Menzel; Andrea Jacobs; Stefanie Engler; Sujana Sivapatham; Anja L. Frei; Gabriele Gut; Joanna Ficek; Nicola Miglino; Rudolf Aebersold; Marina Bacac; Niko Beerenwinkel; Christian Beisel; Bernd Bodenmiller; Reinhard Dummer; Viola Heinzelmann...; Viktor H. Koelzer; Markus G. Manz; Holger Moch; Lucas Pelkmans; Berend Snijder; Alexandre P.A. Th...; Markus Tolnay; Andreas Wicki; Bernd Wollscheid; Gunnar Rätsch; Mitchell P. Levesque; Melike Ak; Faisal S. Al-Quad...; Jonas Albinus; Ilaria Alborelli; Sonali Andani; Per-Olof Attinger; Daniel Baumhoer; Beatrice Beck-Sch...; Lara Bernasconi; Anne Bertolini; Natalia Chicherova; Maya D'Costa; Esther Danenberg; Natalie Davidson; Monica-Andreea Dr...; Martin Erkens; Katja Eschbach; André Fedier; Pedro Ferreira; Bruno Frey; Linda Grob; Detlef Günther; Martina Haberecker; Pirmin Haeuptle; Sylvia Herter; Rene Holtackers; Tamara Huesser; Tim M. Jaeger; Katharina Jahn; Alva R. James; Philip M. Jermann; André Kahles; Abdullah Kahraman; Werner Kuebler; Christian P. Kunze; Christian Kurzeder; Sebastian Lugert; Gerd Maass; Philipp Markolin; Julian M. Metzler; Simone Muenst; Riccardo Murri; Charlotte K.Y. Ng; Stefan Nicolet; Marta Nowak; Patrick G.A. Pedr...; Salvatore Piscuoglio; Mathilde Ritter; Christian Rommel; María L. Rosano-G...; Natascha Santacroce; Ramona Schlenker; Petra C. Schwalie; Severin Schwan; Tobias Schär; Gabriela Senti; Vipin T. Sreedharan; Stefan Stark; Tinu M. Thomas; Vinko Tosevski; Marina Tusup; Audrey Van Drogen; Marcus Vetter; Tatjana Vlajnic; Sandra Weber; Walter P. Weber; Michael Weller; Fabian Wendt; Norbert Wey; Mattheus H.E. Wil...; Shuqing Yu; Johanna Ziegler; Marc Zimmermann; Martin Zoche; Gregor Zuend
• Keywords: Profiling (computer programming); Omics

The application and integration of molecular profiling technologies create novel opportunities for personalized medicine. Here, we introduce the Tumor Profiler Study, an observational trial combining a prospective diagnostic approach to assess the relevance of in-depth tumor profiling to support clinical decision-making with an exploratory approach to improve the biological understanding of the disease.