Adiposity and sex-specific cancer risk

• DOI: 10.1016/j.ccell.2023.05.010
• Publication Date: 2023-06-12T14:42:55Z
• Authors: Mathias Rask-Ande...; Emma Ivansson; Julia Höglund; Weronica E. Ek; Torgny Karlsson; Åsa Johansson
• Keywords: 2. Zero hunger; Male; UK Biobank; obesity; Cancer och onkologi; cox proportional hazard modeling; Liver Neoplasms; body fat distribution; sex-interactions; Medicinsk genetik och genomik; WHRadjBMI; 3. Good health; Medical Genetics and Genomics; BMI; Risk Factors; Cancer and Oncology; cancer; risk factors; Humans; Female; Prospective Studies; Obesity; Medical Genetics; Medicinsk genetik; Adiposity

Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on have rarely studied. Here we estimate the accumulation distribution in females males. We performed a prospective study 442,519 UK Biobank participants, for 19 additional histological subtypes, mean follow-up time 13.4 years. Cox proportional hazard models were used effect 14 different adiposity phenotypes rates, 5% false discovery rate was considered statistically significant. Adiposity-related traits are all but three types, larger number cancers compared distribution. In addition, or exhibit differential sexes colorectal, esophageal, liver cancer.