Application of Langlois’ reagent (NaSO2CF3) in C–H functionalisation

• DOI: 10.1016/j.cclet.2021.09.005
• Publication Date: 2021-09-09T04:33:27Z
• Authors: Jiabin Shen; Jun Xu; Lei He; Chenfeng Liang; Wanmei Li
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract The process of selectively introducing a CF3 group into an organic molecule using inexpensive, stable, and solid sodium trifluoromethanesulfinate has rapidly advanced in recent years to become an eco-friendly method used by organic chemists to synthesize various natural and bioactive molecules. This review focuses on advances made within the last five years regarding C–H functionalisation, namely thermochemical C(sp2)–H (thio)trifluoromethylations, photochemical C(sp2)–H trifluoromethylations, and electrochemical C(sp2)–H trifluoromethylations, using Langlois’ reagent (NaSO2CF3).