Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

• DOI: 10.1016/j.cell.2021.06.020
• Publication Date: 2021-06-17T07:32:57Z
• Authors: Chang Liu; Helen M. Ginn; Wanwisa Dejniratt...; Piyada Supasa; Beibei Wang; Aekkachai Tuekpra...; Rungtiwa Nutalai; Daming Zhou; Alexander J. Mentzer; Yuguang Zhao; Helen M.E. Duyves...; César López-Camacho; Jose Slon-Campos; Thomas S. Walter; Donal Skelly; Sile Ann Johnson; Thomas G. Ritter; Chris Mason; Sue Ann Costa Cle...; Felipe Gomes Naveca; Valdinete Nascimento; Fernanda Nascimento; Cristiano Fernand...; Paola Cristina Re...; Alex Pauvolid-Correa; Marilda M. Siqueira; Christina Dold; Nigel Temperton; Tao Dong; Andrew J. Pollard; Julian C. Knight; Derrick Crook; Teresa Lambe; Elizabeth Clutter...; Sagida Bibi; Amy Flaxman; Mustapha Bittaye; Sandra Belij-Ramm...; Sarah C. Gilbert; Tariq Malik; Miles W. Carroll; Paul Klenerman; Eleanor Barnes; Susanna J. Dunachie; Vicky Baillie; Natali Serafin; Zanele Ditse; Kelly Da Silva; Neil G. Paterson; Mark A. Williams; David R. Hall; Shabir Madhi; Marta C. Nunes; Philip Goulder; Elizabeth E. Fry; Juthathip Mongkol...; Jingshan Ren; David I. Stuart; Gavin R. Screaton
• Keywords: 0301 basic medicine; COVID-19 Vaccines; Immunology; Antigen-Antibody Complex; Coronavirus Disease 2019 Research; FOS: Health sciences; Antibodies, Viral; Crystallography, X-Ray; Diagnostic Methods for COVID-19 Detection; Article; Coronavirus Disease 2019; 03 medical and health sciences; Neutralization; Protein Domains; Neutralization Tests; Virology; Chlorocebus aethiops; Health Sciences; Animals; Humans; Vero Cells; Biology; COVID-19 Serotherapy; Antibody; QR355; Vaccines; SARS-CoV-2; FOS: Clinical medicine; Immunization, Passive; Antibodies, Monoclonal; COVID-19; Antibodies, Neutralizing; Virus; 3. Good health; Infectious Diseases; Antigen; Spike Glycoprotein, Coronavirus; Medicine; Immunization

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 contributed to the current wave of infection ravaging Indian subcontinent and been designated a concern in United Kingdom. Here we study ability monoclonal antibodies convalescent vaccine sera neutralize B.1.617.1 B.1.617.2, complement this structural analyses Fab/receptor binding domain (RBD) complexes, map antigenic space variants. Neutralization both viruses is reduced compared ancestral Wuhan-related strains, but there no evidence widespread antibody escape as seen B.1.351. However, B.1.351 P.1 showed markedly more reduction neutralization suggesting that individuals infected previously by these may be susceptible reinfection B.1.617.2. This observation provides important new insights for immunization policy future vaccines non-immune populations.