Cell death

• DOI: 10.1016/j.cell.2023.11.044
• Publication Date: 2024-01-18T15:30:13Z
• Authors: Kim Newton; Andreas Strasser; Nobuhiko Kayagaki; Vishva M. Dixit
• Keywords: Cell Death; Pyroptosis; Humans; Ferroptosis; Homeostasis; Apoptosis; Signal Transduction

Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. It also curtails the spread of pathogens eliminating infected can be induced genetically programmed suicide mechanisms apoptosis, necroptosis, pyroptosis, it a consequence dysregulated metabolism, as in ferroptosis. Here, we review signaling underlying each cell-death pathway, discuss how impaired excessive activation distinct processes promote disease, highlight existing potential therapies for redressing imbalances cell cancer other diseases.