An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania

• DOI: 10.1016/j.cell.2024.10.005
• Publication Date: 2024-10-29T20:24:53Z
• Authors: Liyen Loh; Philippa M. Saunders; Camilla Faoro; Neus Font-Porterias; Neda Nemat-Gorgani; Genelle F. Harrison; Suraju Sadeeq; Luca Hensen; Shu Cheng Wong; Jacqueline Widjaja; E. Bridie Clemens; Shiying Zhu; Katherine M. Kichula; Sudan Tao; Faming Zhu; Gonzalo Montero-M...; Marcelo Fernandez...; Lisbeth A. Guethlein; Julian P. Vivian; Jane Davies; Alexander J. Mentzer; Stephen J. Oppenh...; William Pomat; Alexander G. Ioan...; Carmina Barberena...; Andrés Moreno-Est...; Adrian Miller; Peter Parham; Jamie Rossjohn; Steven Y.C. Tong; Katherine Kedzierska; Andrew G. Brooks; Paul J. Norman

Genetic variation in host immunity impacts the disproportionate burden of infectious diseases that can be experienced by First Nations peoples. Polymorphic human leukocyte antigen (HLA) class I and killer cell immunoglobulin-like receptors (KIRs) are key regulators natural (NK) cells, which mediate early infection control. How this their responses across populations is unclear. We show HLA-A