Injury Signals Cooperate with Nf1 Loss to Relieve the Tumor-Suppressive Environment of Adult Peripheral Nerve

• DOI: 10.1016/j.celrep.2013.08.033
• Publication Date: 2013-09-26T16:07:09Z
• Authors: Sara Ribeiro; Ilaria Napoli; Ian J. White; Simona Parrinello; Adrienne M. Flanagan; Ueli Suter; Luis F. Parada; Alison C. Lloyd
• Keywords: Peripheral nerve injury; Nerve Injury

Schwann cells are highly plastic that dedifferentiate to a progenitor-like state following injury. However, deregulation of this plasticity, may be involved in the formation neurofibromas, mixed-cell tumors cell (SC) origin arise upon loss NF1. Here, we show adult myelinating SCs (mSCs) refractory Nf1 loss. context injury, Nf1-deficient display opposing behaviors along wounded nerve; distal Nf1−/− mSCs redifferentiate normally, whereas at wound site give rise neurofibromas both Nf1+/+ and Nf1+/− backgrounds. Tracing experiments showed distinct types within tumor derive from SCs. This model neurofibroma demonstrates can originate nerve environment switch suppressive promoting These findings have implications for characterization treatment neurofibromas.