Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis

• DOI: 10.1016/j.celrep.2014.02.004
• Publication Date: 2014-02-27T17:15:45Z
• Authors: Jian Cao; Zongzhi Liu; William K.C. Cheung; Minghui Zhao; Sophia Y. Chen; Siew Wee Chan; Carmen J. Booth; Don X. Nguyen; Qin Yan
• Keywords: Demethylase; Tumor progression; Tumor initiation

Metastasis is a major clinical challenge for cancer treatment. Emerging evidence suggests that aberrant epigenetic modifications contribute significantly to tumor formation and progression. However, the drivers roles of such changes in metastasis are still poorly understood. Using bioinformatic analysis human breast gene-expression data sets, we identified histone demethylase RBP2 as putative mediator metastatic By using both cells genetically engineered mice, demonstrated critical lung multiple vivo models. Mechanistically, promotes pleiotropic positive regulator many genes, including TNC. In addition, loss suppresses MMTV-neu transgenic mice. These results suggest therapeutic targeting potential strategy inhibition progression metastasis.