Interleukin-17D Mediates Tumor Rejection through Recruitment of Natural Killer Cells

• DOI: 10.1016/j.celrep.2014.03.073
• Publication Date: 2014-05-01T15:48:55Z
• Authors: Timothy O’Sullivan; Robert Saddawi-Ko...; Emilie Gross; Miller Tran; Stephen P. Mayfield; Hiroaki Ikeda; Jack D. Bui
• Keywords: Immunoediting

The process of cancer immunoediting generates a repertoire cells that can persist in immune-competent hosts. In its most complex form, this begins with the elimination highly immunogenic unedited tumor followed by escape less edited cells. Although tumors release immunosuppressive factors, it is unknown whether produce cytokines enhance antitumor function. Utilizing gene microarray analysis, we found cytokine interleukin 17D (IL-17D) was expressed certain but not mouse cell lines. Moreover, forced expression IL-17D induced rejection stimulating MCP-1 production from endothelial cells, leading to recruitment natural killer (NK) NK promoted M1 macrophage development and adaptive immune responses. also decreased high-grade metastatic human tumors, suggesting be targeted for therapy.