MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons

• DOI: 10.1016/j.celrep.2014.03.075
• Publication Date: 2014-05-01T11:47:43Z
• Authors: Marie-Laure Volvert; Pierre-Paul Prévot; Pierre Close; Sophie Laguesse; Sophie Pirotte; James Hemphill; Florence Rogister; Nathalie Kruzy; Rosalie Sacheli; Gustave Moonen; Alexander Deiters; Matthias Merkensc...; Alain Chariot; Brigitte Malgrange; Juliette D. Godin; Laurent Nguyen
• Keywords: Corticogenesis; Cell polarity; Doublecortin

The migration of cortical projection neurons is a multistep process characterized by dynamic cell shape remodeling. molecular basis these changes remains elusive, and the present work describes how microRNAs (miRNAs) control neuronal polarization during radial migration. We show that miR-22 miR-124 are expressed in wall where they target components CoREST/REST transcriptional repressor complex, thereby regulating doublecortin transcription migrating neurons. This pathway underlies promoting multipolar-bipolar conversion at early phases migration, later stabilization polarity to support locomotion on glia fibers. Thus, our emphasizes key roles some miRNAs cerebral corticogenesis.