Appropriate Crypt Formation in the Uterus for Embryo Homing and Implantation Requires Wnt5a-ROR Signaling

• DOI: 10.1016/j.celrep.2014.06.027
• Publication Date: 2014-07-17T15:46:54Z
• Authors: Jeeyeon Cha; Amanda Bartos; Craig Park; Xiaofei Sun; Yingju Li; Sang-Wook Cha; Rieko Ajima; Hsin-Yi Henry Ho; Terry P. Yamaguchi; Sudhansu K. Dey
• Keywords: Decidualization; Placentation; Trophoblast

Embryo homing and implantation occur within a crypt (implantation chamber) at the antimesometrial (AM) pole along uterus. The mechanism by which this is achieved not known. Here, we show that villi-like epithelial projections from main uterine lumen toward AM regularly spaced intervals form crypts for embryo were disrupted in mice with loss or gain of function Wnt5a, both Ror1 Ror2. This disruption Wnt5a-ROR signaling resulted disorderly projections, formation, spacing, impaired implantation. These early disturbances under abnormal reflected adverse late pregnancy events, including defective decidualization placentation, ultimately leading to compromised outcomes. study presents deeper insight regarding formation organized success.