In Vivo Tissue-wide Synchronization of Mitochondrial Metabolic Oscillations

• DOI: 10.1016/j.celrep.2014.09.022
• Publication Date: 2014-10-16T15:46:51Z
• Authors: Natalie Porat-Shliom; Yun Chen; Muhibullah Tora; Akiko Shitara; Andrius Masedunskas; Roberto Weigert
• Keywords: Multicellular organism; Intravital microscopy

Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms situ. Using intravital microscopy live animals, we report that undergoes rapid and periodic oscillations under basal conditions. Notably, mitochondria vivo behave as a network functionally coupled oscillators, which maintain high level throughout tissue via activity gap junctions. These findings reveal unique aspect relationship between architecture self-organization vivo.