Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man

• DOI: 10.1016/j.celrep.2015.10.034
• Publication Date: 2015-11-12T19:47:32Z
• Authors: Beatrice Bolinger; Stuart Sims; Leo Swadling; Geraldine O’Hara; Catherine de Lara; Dilair Baban; Natasha Saghal; Lian Ni Lee; Emanuele Marchi; Mark Davis; Evan Newell; Stefania Capone; Antonella Folgori; Ellie Barnes; Paul Klenerman
• Keywords: 0303 health sciences; QH301-705.5; Genetic Vectors; Vaccination; Cytomegalovirus; Apoptosis; Cell Differentiation; CD8-Positive T-Lymphocytes; Lymphocyte Activation; Adenoviridae; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Report; Animals; Humans; Biology (General); Immunologic Memory; Transcription Factors

Following exposure to vaccines, antigen-specific CD8+ T cell responses develop as long-term memory pools. Vaccine strategies based on adenoviral vectors, e.g., those developed for HCV, are able induce and sustain substantial populations. How such populations evolve following vaccination remains be defined at a transcriptional level. We addressed the regulation of divergent pools induced by an adenovector encoding model antigen (beta-galactosidase). observe profiles that mimic infection with persistent pathogens, murine human cytomegalovirus (CMV). Key hallmarks include upregulation homing receptors anti-apoptotic pathways, driven conserved networks transcription factors, including T-bet. In humans, adenovirus vaccine similar CMV-like phenotypes factor regulation. These data clarify core features adenovectors indicate pathway development shared herpesviruses.