The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

• DOI: 10.1016/j.celrep.2015.10.049
• Publication Date: 2015-11-19T18:28:49Z
• Authors: Ana Sofia Rocha; Valerie Vidal; Marjolijn Mertz; Timothy J. Kendall; Aurelie Charlet; Hitoshi Okamoto; Andreas Schedl
• Keywords: Factor (programming language)

Liver zonation, the spatial separation of different metabolic pathways along liver sinusoids, is fundamental for proper functioning this organ, and its disruption can lead to development disorders such as hyperammonemia. Metabolic zonation involves induction β-catenin signaling around central veins, but how patterned activity established maintained unclear. Here, we show that molecule Rspondin3 specifically expressed within endothelial compartment vein. Conditional deletion Rspo3 in mice disrupts activation fate, demonstrating crucial role determining maintaining β-catenin-dependent zonation. Moreover, ectopic expression Rspo1, a close family member Rspo3, induces pericentral markers, Rspondins be sufficient imprint more fate. Thus, key angiocrine factor controls hepatocytes.