Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior

• DOI: 10.1016/j.celrep.2015.11.064
• Publication Date: 2015-12-24T18:50:31Z
• Authors: Kyogo Kobayashi; Shunji Nakano; Mutsuki Amano; Daisuke Tsuboi; Tomoki Nishioka; Shingo Ikeda; Genta Yokoyama; Kozo Kaibuchi; Ikue Mori
• Keywords: Neural cell; Biological neural network

Highlights•A single thermosensory neuron is capable of memorizing a temperature•This single-cell memory shows variability between individuals•The CaMKI/IV and Raf pathway modulates in memory•The the underlies premotor activitySummaryUnveiling molecular cellular mechanisms underlying has been challenge for past few decades. Although synaptic plasticity proven to be essential formation, significance "single-cell memory" still remains elusive. Here, we exploited primary culture system analysis C. elegans neurons show that an ability form, retain, reset temperature memory. Genetic proteomic analyses found expression exhibits inter-individual variability, which controlled by evolutionarily conserved pathway. The variable responses sensory influenced neural activity downstream interneurons, suggesting modulation ultimately determines behavioral output elegans. Our results provide proof suggest individual differences at level can confer individuality.Graphical abstract