Tumor-Induced Hyperlipidemia Contributes to Tumor Growth

• DOI: 10.1016/j.celrep.2016.03.020
• Publication Date: 2016-04-02T02:34:09Z
• Authors: Jianfeng Huang; Lena Li; Jihong Lian; Silvia Schauer; Paul W. Vesely; Dagmar Kratky; Gerald Hoefler; Richard Lehner
• Keywords: Hyperlipidemia

The known link between obesity and cancer suggests an important interaction the host lipid metabolism tumorigenesis. Here, we used a syngeneic tumor graft model to demonstrate that development influences metabolism. BCR-Abl-transformed precursor B cell tumors induced hyperlipidemia by stimulating very low-density lipoprotein (VLDL) production blunting VLDL (LDL) turnover. To assess whether progression was dependent on tumor-induced hyperlipidemia, utilized production-deficient mouse model, carboxylesterase3/triacylglycerol hydrolase (Ces3/TGH) knockout mice. In Ces3/Tgh−/− tumor-bearing mice, plasma triglyceride cholesterol levels were attenuated. Importantly weight reduced in Mechanistically, growth mice attributed reversal of PCSK9-mediated degradation hepatic LDLR decrease LDL Our data encompasses feed-forward loop reprograms homeostasis part providing support growth.