MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis

• DOI: 10.1016/j.celrep.2016.09.024
• Publication Date: 2016-10-04T16:47:10Z
• Authors: Francisca F. Vasc...; Alessandro Sessa; Cátia Laranjeira; Alexandre A.S.F. ...; Vera Teixeira; Daniel W. Hagey; Diogo M. Tomaz; Jonas Muhr; Vania Broccoli; Diogo S. Castro
• Keywords: HES1; Progenitor; Proneural genes; Cell fate determination

The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated less is known on mechanisms suppress progenitor cell identity. Here, we show Ascl1 induces factor MyT1 while promoting neuronal differentiation. We combined functional during neurogenesis with characterization its transcriptional program. binding associated repression cells. It promotes counteracting inhibitory activity Notch signaling at multiple levels, targeting Notch1 receptor and many downstream targets. These include regulators program, Hes1, Sox2, Id3, Olig1. Thus, suppresses cell-autonomously via MyT1, coupling fate.