Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity

• DOI: 10.1016/j.celrep.2017.04.024
• Publication Date: 2017-05-02T16:16:14Z
• Authors: Sarah Melzer; Mariana Gil; David E. Koser; Magdalena Michael; Kee Wui Huang; Hannah Monyer
• Keywords: Medium spiny neuron

Highlights•Long-range GABAergic projections from the motor cortex directly innervate striatum•M1 and M2 long-range SOM+ PV+ neurons differentially striatal neurons•Striatal cholinergic are innervated mainly by M1 projecting neurons•Motor modulate locomotionSummaryThe cortico-basal ganglion loop is critical for planning, execution, learning. Balanced excitation inhibition in this crucial proper output. Excitatory have been thought to be only source of cortical input striatum. Here, we identify primary (M1) secondary (M2) that target dorsal This population comprises both somatostatin-positive (SOM+) parvalbumin-positive (PV+) direct indirect pathway output as well interneurons differentially. Notably, optogenetic stimulation reduced locomotion, whereas enhanced locomotion. Thus, corticostriatal activity.Graphical abstract