Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

• DOI: 10.1016/j.celrep.2017.07.065
• Publication Date: 2017-08-15T16:16:38Z
• Authors: Daniel Mauvoisin; Florian Atger; Loïc Dayon; Antonio Núñez Gal...; Jingkui Wang; Eva Martin; Laetitia Da Silva; Ivan Montoliu; Sebastiano Collino; Francois-Pierre M...; Joanna Ratajczak; Carles Cantó; Martin Kussmann; Felix Naef; Frédéric Gachon
• Keywords: SIRT3

Lysine acetylation is involved in various biological processes and considered a key reversible post-translational modification the regulation of gene expression, enzyme activity, subcellular localization. This therefore highly relevant context circadian biology, but its characterization on proteome-wide scale clock dependence are still poorly described. Here, we provide comprehensive rhythmic acetylome map mouse liver. Rhythmic acetylated proteins showed localization-specific phases that correlated with related metabolites regulated pathways. Mitochondrial were over-represented among rhythmically SIRT3-dependent deacetylation. SIRT3 activity being nicotinamide adenine dinucleotide (NAD)+ level-dependent, show NAD+ orchestrated by both feeding rhythms through salvage pathway also via riboside pathway. Hence, diurnal relies functional affects important metabolic pathways