High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

• DOI: 10.1016/j.celrep.2018.03.129
• Publication Date: 2018-05-02T08:10:02Z
• Authors: Andrea Wilderman; Jennifer VanOuden...; Jeffrey Kron; James P. Noonan; Justin Cotney
• Keywords: Craniofacial abnormality; Epigenomics

Defects in patterning during human embryonic development frequently result craniofacial abnormalities. The gene regulatory programs that build the complex are likely controlled by information located between genes and within intronic sequences. However, systematic identification of sequences important for forming face has not been performed. Here, we describe comprehensive epigenomic annotations from tissues comparisons with multiple cell types. We identified thousands tissue-specific causal regions rare demonstrate significant enrichment common variants associated orofacial clefting enhancers active early development, while those normal facial variation enriched near end period. These data provided easily accessible formats both researchers clinicians to aid future experimental design interpretation noncoding affected