Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

• DOI: 10.1016/j.celrep.2019.02.034
• Publication Date: 2019-03-12T14:43:30Z
• Authors: Emily A. Thompson; Jason S. Mitchell; Lalit K. Beura; David J. Torres; Paulus Mrass; Mark J. Pierson; Judy L. Cannon; David Masopust; Brian T. Fife; Vaiva Vezys
• Keywords: Intraepithelial lymphocyte

The migratory capacity of adaptive CD8αβ T cells dictates their ability to locate target and exert cytotoxicity, which is the basis immune surveillance for containment microbes disease. small intestine (SI) largest mucosal surface a primary site pathogen entrance. Using two-photon laser scanning microscopy, we found that motility antigen (Ag)-specific in SI dynamic varies with environmental milieu. Pathogen-specific cell movement differed throughout infection, becoming locally confined at memory. Motility was not dependent on CD103 but influenced by micro-anatomical locations within inflammation. CD8 responding self-protein were initially affected presence self-Ag, this altered after complete tolerance induction. These studies identify multiple factors affect intestinal mucosa show adaptability motility.