Chlamydia trachomatis CT229 Subverts Rab GTPase-Dependent CCV Trafficking Pathways to Promote Chlamydial Infection

• DOI: 10.1016/j.celrep.2019.02.079
• Publication Date: 2019-03-19T15:23:04Z
• Authors: Robert Faris; Marlena Merling; Shelby E. Andersen; Cheryl A. Dooley; Ted Hackstadt; Mary M. Weber
• Keywords: Rab; Small GTPase

Chlamydial infection requires the formation of a membrane-bound vacuole, termed inclusion, that undergoes extensive interactions with select host organelles. The importance Inc protein CT229 in and maintenance chlamydial inclusion was recently highlighted by studies demonstrating its absence during results reduced bacterial replication, premature lysis, cell death. Previous reports have indicated binds Rab GTPases; however, physiological implications this interaction are unknown. Here, we show regulates multivesicular trafficking recruiting multiple GTPases their cognate effectors to inclusion. We demonstrate specifically modulates clathrin-coated vesicle transferrin mannose-6-phosphate receptor, both which crucial for proper development. This study highlights as master regulator vesicular pathways essential infection.