miR-29a/b1 Inhibits Hair Follicle Stem Cell Lineage Progression by Spatiotemporally Suppressing WNT and BMP Signaling

• DOI: 10.1016/j.celrep.2019.10.062
• Publication Date: 2019-11-19T15:45:33Z
• Authors: Mengxu Ge; Chuncheng Liu; Lei Li; Miaomiao Lan; Yingying Yu; Lijie Gu; Yang Su; Kuo Zhang; Yuying Zhang; Tongtong Wang; Chang Liu; Fan Liu; Min Li; Lei Xiong; Kun Wang; Ting He; Yunping Dai; Yaofeng Zhao; Ning Li; Zhengquan Yu; Qingyong Meng
• Keywords: Lineage (genetic)

Hair follicle stem cells (HFSCs) and subsequent generations of matrix progeny make lineage choices by responding to spatiotemporal signals; however, the cues driving that specification are not well understood. Here, we demonstrate dynamics microRNA (miR)-29 expression inversely proportional HFSC progression. Furthermore, show sustained miR-29a/b1 overexpression in anagen or telogen mice causes a short-hair phenotype eventual hair loss inhibiting proliferation HFSCs likely preventing their differentiation. Conversely, loss-of-function vivo model, deficiency accelerates progression telogen. Mechanistically, blocks spatiotemporally targeting Ctnnb1, Lrp6, Bmpr1a, Ccna2. We further skin-specific Lrp6 Bmpr1a ablation partially accounts for phenotype. Overall, these synergistic targets reveal as high-fidelity antagonist potential therapeutic target loss.