The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

• DOI: 10.1016/j.celrep.2020.02.045
• Publication Date: 2020-03-10T15:09:39Z
• Authors: Dennis B. Nestvogel; Ricardo Martins M...; Carolina Leon-Pinzon; Manuel Schottdorf; ChoongKu Lee; Cordelia Imig; Nils Brose; Jeong-Seop Rhee
• Keywords: Priming (agriculture)

Short-term plasticity gates information transfer across neuronal synapses and is thought to be involved in fundamental brain processes, such as cortical gain control sensory adaptation. Neurons employ synaptic vesicle priming proteins of the CAPS Munc13 families shape short-term vitro, but relevance this phenomenon for processing intact unknown. By combining stimulation with vivo patch-clamp recordings anesthetized mice, we show that genetic deletion CAPS-1 thalamic neurons results more rapid adaptation sensory-evoked subthreshold responses layer 4 primary visual cortex. Optogenetic experiments acute slices further reveal enhanced caused by pronounced depression. Our data indicate engage CAPS-family optimal between vivo.