STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

• DOI: 10.1016/j.celrep.2020.107771
• Publication Date: 2020-06-16T14:34:45Z
• Authors: Brock G. Bennion; Carys A. Croft; Teresa L. Ai; Wei Qian; Amber M. Menos; Cathrine A. Miner; Marie-Louis Frémond; Jean-Marc Doisne; Prabhakar S. Andhey; Derek J. Platt; Jennifer K. Bando; Erin R. Wang; Hella Luksch; Thierry J. Molina; Elisha D.O. Roberson; Maxim N. Artyomov; Angela Rösen-Wolff; Marco Colonna; Frédéric Rieux-La...; James P. Di Santo; Bénédicte Neven; Jonathan J. Miner
• Keywords: Sting; Innate lymphoid cell

STING gain-of-function causes autoimmunity and immunodeficiency in mice STING-associated vasculopathy with onset infancy (SAVI) humans. Here, we report that prevents development of lymph nodes Peyer's patches. We show the absence secondary lymphoid organs is associated diminished numbers innate cells (ILCs), including tissue inducer (LTi) cells. Although wild-type (WT) α4β7+ progenitors differentiate efficiently into LTi cells, do not. Furthermore, impairs all types ILCs. Patients mutations have fewer ILCs, although they still nodes. In mice, expression mutant RORγT-positive lineages reduces RORγT lineage-specific also lung disease. Since expressed exclusively during fetal development, our findings suggest node organogenesis by reducing cell mice.