Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma

• DOI: 10.1016/j.celrep.2020.108340
• Publication Date: 2020-11-03T20:23:50Z
• Authors: Yun Yang; Guimin Zhang; Fengzhu Guo; Qiqi Li; Hui Luo; Yang Shu; Yuge Shen; Jia Gan; Lin Xu; Hanshuo Yang
• Keywords: Bioenergetics; Hypoxia; Anaerobic glycolysis; Mitochondrial ROS; Reprogramming

Bioenergetic reprogramming during hypoxia adaption is critical to promote hepatocellular carcinoma (HCC) growth and progression. However, the mechanism underlying orchestration of mitochondrial OXPHOS (oxidative phosphorylation) glycolysis in not fully understood. Here, we report that UQCC3 (C11orf83) expression increases correlates with poor prognosis HCC patients. Loss impairs cell proliferation vitro vivo. Mechanistically, forms a positive feedback loop reactive oxygen species (ROS) sustain ROS generation hypoxic cells subsequently maintains structure function stabilizes HIF-1α enhance under hypoxia. Thus, plays an indispensable role for bioenergetic by simultaneously regulating glycolysis. The between indicates self-modulating model within mitochondria initiates adaptation stress.