Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen

• DOI: 10.1016/j.celrep.2021.108861
• Publication Date: 2021-03-18T21:16:44Z
• Authors: Viola L. Boccasavia; Elena R. Bovolenta; Ana Villanueva; Aldo Borroto; Clara L. Oeste; Hisse M. van Santen; Cristina Prieto; Diego Alonso-López; Manuel D. Diaz-Muñoz; Facundo D. Batista; Balbino Alarcón
• Keywords: rho GTP-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Transcription, Genetic; limiting antigen; T-Lymphocytes, Regulatory; Article; 03 medical and health sciences; CD28 Antigens; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Animals; trogocytosis; Antigens; vaccine dosing; Antigen Presentation; 0303 health sciences; [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology; Genome; Limiting antigen; Cell Membrane; Histocompatibility Antigens Class II; Cell Polarity; Cell Differentiation; Dendritic Cells; antigen presentation by T cells; Trogocytosis; 3. Good health; Treg; Mice, Inbred C57BL; Disease Models, Animal; Gene Expression Regulation; Antigen presentation by T cells; [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases; Vaccine dosing; Th17 Cells; Th17; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

T cells form immunological synapses with professional antigen-presenting (APCs) resulting in cell activation and the acquisition of peptide antigen-MHC (pMHC) complexes from plasma membrane APC. They thus become APCs themselves. We investigate functional outcome T-T antigen presentation by CD4 find that (Tpres) predominantly differentiate into regulatory (Treg), whereas have been stimulated Tpres Th17 pro-inflammatory cells. Using mice deficient pMHC uptake cells, we show is important for development experimental autoimmune encephalitis differentiation vivo. By varying APC:T ratio, can modulate Treg versus vitro vivo, suggesting underlies proinflammatory responses conditions scarcity.