Influence of the microenvironment on modulation of the host response by typhoid toxin

• DOI: 10.1016/j.celrep.2021.108931
• Publication Date: 2021-04-06T15:38:29Z
• Authors: Océane C.B. Martin; Anna Bergonzini; Maria Lopez Chilo...; Eleni Paparouna; Deborah Butter; Sofia D.P. Theodorou; Maria M. Haykal; Elisa Boutet-Robinet; Toma Tebaldi; Andrew Wakeham; Mikael Rhen; Vassilis G. Gorgo...; Tak Mak; Ioannis S. Pateras; Teresa Frisan
• Keywords: Crosstalk; Proinflammatory cytokine

Bacterial genotoxins cause DNA damage in eukaryotic cells, resulting activation of the response (DDR) vitro. These toxins are produced by Gram-negative bacteria, enriched microbiota inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients. However, their role infection remains poorly characterized. We address typhoid toxin modulation host-microbial interaction health disease. Infection with a genotoxigenic Salmonella protects mice from intestinal inflammation. show that presence an active genotoxin promotes fragmentation senescence vivo, which is uncoupled unexpectedly associated induction anti-inflammatory environment. The lost when occurs acute colitis. data highlight complex context-dependent crosstalk between bacterial-genotoxin-induced DDR host immune response, underlining unexpected for bacterial genotoxins.