Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity

• DOI: 10.1016/j.celrep.2021.109018
• Publication Date: 2021-04-21T04:30:29Z
• Authors: Rodrigo W. Alves ...; David Gallo; Ghee Rye Lee; Eri Katsuyama; Alexa Schaufler; Janick Weber; Eva Csizmadia; George C. Tsokos; Lauren G. Koch; Steven L. Britton; Ulrik Wisløff; Patricia C. Brum; Leo E. Otterbein
• Keywords: HMOX1; Muscle Atrophy

Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation skeletal muscle function at molecular level after remains unclear. We tested hypothesis that benefits are linked partly microtraumatic events result in accumulation circulating heme. Effective metabolism heme is controlled by Heme Oxygenase-1 (HO-1, Hmox1), we find mouse muscle-specific HO-1 deletion (Tam-Cre-HSA-Hmox1fl/fl) shifts proportion fibers from type IIA IIB concomitant with a disruption mitochondrial content function. In addition significant impairment running performance response training, Tam-Cre-HSA-Hmox1fl/fl mice show remarkable atrophy compared Hmox1fl/fl controls. Collectively, these data define role for as central regulators physiologic exercise.