Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

• DOI: 10.1016/j.celrep.2021.109128
• Publication Date: 2021-05-18T15:19:39Z
• Authors: Jaimarie Sostre-C...; Kahealani Uehara; Anna E. Garcia Wh...; Matthew J. Gavin; Jeff Ishibashi; Matthew J. Potthoff; Patrick Seale; Paul M. Titchenell
• Keywords: FGF21; FOXO1

Organismal stressors such as cold exposure require a systemic response to maintain body temperature. Brown adipose tissue (BAT) is key thermogenic in mammals that protects against hypothermia exposure. Defining the complex interplay of multiple organ systems this fundamental our understanding thermogenesis. In study, we identify role for hepatic insulin signaling via AKT adaptive stress and show liver an essential cell-nonautonomous regulator adipocyte lipolysis BAT function. Mechanistically, inhibition forkhead box O1 (FOXO1) by controls thermogenesis enhancing catecholamine-induced white (WAT) increasing circulating fibroblast growth factor 21 (FGF21). Our data AKT-FOXO1 axis regulating WAT lipolysis, promoting capacity, ensuring proper acute