Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection

• DOI: 10.1016/j.celrep.2021.109159
• Publication Date: 2021-05-18T15:24:20Z
• Authors: Xiaoyuan Bai; Wenxian Yang; Xiaohan Luan; Huizi Li; Heqiao Li; Deyu Tian; Wenhui Fan; Jing Li; Beinan Wang; Wenjun Liu; Lei Sun
• Keywords: Cypa

During influenza A epidemics, bacterial coinfection is a major cause of increased morbidity and mortality. However, the roles host factors in regulating virus (IAV)-triggered remain elusive. Cyclophilin (CypA) an important regulator infection immunity. Here, we show that IAV-induced CypA expression facilitates group Streptococcus (GAS) both vitro vivo. Upon IAV infection, interacts with focal adhesion kinase (FAK) inhibited E3 ligase cCbl-mediated, K48-linked ubiquitination FAK, which positively regulates integrin α5 actin rearrangement via FAK/Akt signaling pathway to facilitate GAS colonization invasion. Notably, deficiency or inhibition by cyclosporine significantly inhibits IAV-triggered mice. Collectively, these findings reveal critical for induction another way promote coinfection, suggesting promising therapeutic target secondary infection.