Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

• DOI: 10.1016/j.celrep.2021.109367
• Publication Date: 2021-07-13T15:07:50Z
• Authors: Jasper E. Neggers; Brenton R. Paolella; Adhana Asfaw; Michael V. Rothberg; Thomas A. Skipper; Annan Yang; Radha L. Kalekar; John M. Krill-Burger; Neekesh V. Dharia; Guillaume Kugener; Jérémie Kalfon; Chen Yuan; Nancy Dumont; Alfredo Gonzalez; Mai Abdusamad; Yvonne Y. Li; Liam F. Spurr; Westley W. Wu; Adam D. Durbin; Brian M. Wolpin; Federica Piccioni; David E. Root; Jesse S. Boehm; Andrew D. Cherniack; Aviad Tsherniak; Andrew L. Hong; William C. Hahn; Kimberly Stegmaier; Todd R. Golub; Francisca Vazquez; Andrew J. Aguirre
• Keywords: ESCRT

(Cell Reports 33, 108493-1–19.e1–e16; December 15, 2020) In the originally published version of this paper, CHMP4B sgRNA sequence listed in STAR Methods section was incorrect. The incorrect 5′-TCGATGGCACAAGCCATGAA, which is an designed to target CHMP2A. correct CHMP4B-targeting that used experiments for paper 5′- TATCAACCATCGAGTTCCAG. This change does not affect data or conclusions study and now appears online. authors apologize any inconvenience error may have caused. Synthetic Lethal Interaction between ESCRT Paralog Enzymes VPS4A VPS4B Cancers Harboring Loss Chromosome 18q 16qNeggers et al.Cell ReportsDecember 2020In BriefNeggers al. identify ATPases as selective vulnerabilities potential therapeutic targets cancers harboring loss chromosome 16q. VPS4B-deficient cancers, suppression leads ESCRT-III dysfunction, nuclear deformation, abscission defects. Moreover, proteins interferons can modulate dependency on VPS4A. Full-Text PDF Open Access