IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus

• DOI: 10.1016/j.celrep.2021.110126
• Publication Date: 2021-12-03T06:47:03Z
• Authors: Yang Yu; Na Xu; Qi Cheng; Fei Deng; Meiqin Liu; Airu Zhu; Yuan-Qin Min; Dan Zhu; Wenbo Huang; Xu Feng; Xizhong Jing; Ying Chen; Daoyuan Yue; Yawei Fan; Chang Shu; Qing Guan; Zifeng Yang; Jincun Zhao; Wenjun Song; Deyin Guo; Huanliang Liu; Jindong Zhao; Ping Lan; Zhengli Shi; Yingfang Liu; Xiaoping Chen; Huanhuan Liang
• Keywords: Cytokine Storm; Coronavirus

Previous studies have shown that the high mortality caused by viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus primarily results from complications of a cytokine storm. Therefore, it is critical to identify key factors participating in Here we demonstrate interferon-induced protein 35 (IFP35) plays an important role storm induced SARS-CoV-2 infection. We find levels serum IFP35 individuals with correlates severity syndrome. Using mouse model cell assays, show released lung epithelial cells macrophages after or In addition, administration neutralizing antibodies against considerably reduces injury and, thus, rate mice exposed viral Our findings suggest serves biomarker therapeutic target virus-induced syndromes.