Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity

• DOI: 10.1016/j.celrep.2022.111209
• Publication Date: 2022-08-16T14:47:51Z
• Authors: Lorenzo Gesuita; Anna Cavaccini; Ali Özgür Argunsah; Emilia Favuzzi; Leena Ali Ibrahim; Tevye Jason Stach...; Martina De Gennaro; Sebastian Utz; Melanie Greter; Theofanis Karayannis
• Keywords: Cortical neurons

Microglia play a key role in shaping the formation and refinement of excitatory network brain. However, less is known about whether how they organize development distinct inhibitory networks. We find that microglia are essential for proper somatostatin-positive (SST+) cell synapses during second postnatal week. further identify pair molecules act antagonistically to one another organization SST+ axonal elaboration. Whereas CX3CL1 acts suppress growth complexity, CXCL12 promotes it. Assessing functional importance cortical activity, we whisker stimulation paradigm drives activation leads reduced spiking brains depleted microglia. Collectively, our data demonstrate an important regulating output early life.