An anillin-CIN85-SEPT9 complex promotes intercellular bridge maturation required for successful cytokinesis

• DOI: 10.1016/j.celrep.2022.111274
• Publication Date: 2022-08-30T14:31:55Z
• Authors: Thomas C. Panagiotou; Anan Chen; Andrew Wilde
• Keywords: Bridge (graph theory); Septin

Cleavage of one cell into two is the most dramatic event in life a cell. Plasma membrane fission occurs within narrow intercellular bridge (ICB) between daughter cells, but mechanisms underlying ICB formation and maturation are poorly understood. Here we identify CIN85 as an assembly factor demonstrate its requirement for robust timely cytokinesis. interacts directly with N-terminal region anillin SEPT9 thereby facilitates SEPT9-containing filament localization to plasma ICB. In contrast, C-terminal pleckstrin homology (PH) domain binds septin units lacking enriched SEPT11. Anillin's interactions distinct required promote elongation that, propose, generate physical space which abscission machinery recruited drive final scission releasing independent cells.