Microglial control of neuronal development via somatic purinergic junctions

• DOI: 10.1016/j.celrep.2022.111369
• Publication Date: 2022-09-20T14:48:55Z
• Authors: Csaba Cserép; Anett D. Schwarcz; Balázs Pósfai; Zsófia I. László; Anna Kellermayer; Zsuzsanna Környei; Máté Kisfali; Miklós Nyerges; Zsolt Lele; István Katona; Ádám Dénes
• Keywords: Cytoarchitecture; Purinergic Signalling

Microglia, the resident immune cells of brain, play important roles during development. Although bi-directional communication between microglia and neuronal progenitors or immature neurons has been demonstrated, main sites interaction underlying mechanisms remain elusive. By using advanced methods, here we provide evidence that microglial processes form specialized contacts with cell bodies developing throughout embryonic, early postnatal, adult neurogenesis. These developmental are highly reminiscent somatic purinergic junctions instrumental for microglia-neuron in brain. The formation maintenance these is regulated by functional P2Y12 receptors, deletion P2Y12Rs disturbs proliferation precursors leads to aberrant cortical cytoarchitecture development adulthood. We propose represents an interface monitor status control neurodevelopment.