Cell-type identity of the avian utricle

• DOI: 10.1016/j.celrep.2022.111432
• Publication Date: 2022-09-27T10:38:37Z
• Authors: Mirko Scheibinger; Amanda Janesick; Nesrine Benkafadar; Daniel C. Ellwanger; Taha A. Jan; Stefan Heller
• Keywords: Utricle; Cell type; Saccule

The avian utricle, a vestibular organ of the inner ear, displays turnover sensory hair cells throughout life. This is in sharp contrast to mammalian which shows limited regenerative capacity. Here, we use single-cell RNA sequencing identify distinct marker genes for different cell subtypes chicken validated situ. We provide markers spatially supporting populations and two transitional dedifferentiating developing cells. Trajectory reconstruction resulted an inventory gene expression dynamics natural generation utricle.