Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst

• DOI: 10.1016/j.celrep.2023.112064
• Publication Date: 2023-02-01T01:28:15Z
• Authors: Kira L. Tomlinson; Sebastián A. Riqu...; Swikrity Upadhyay...; Marija Drikic; Ian R. Monk; Timothy P. Stinear; Ian A. Lewis; Alice S. Prince
• Keywords: Respiratory burst

Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even setting of robust neutrophil response, S. aureus can evade immune clearance. Here, we demonstrate that impairs function by triggering production anti-inflammatory metabolite itaconate. The enzyme synthesizes itaconate, Irg1, is selectively expressed neutrophils during pneumonia. Itaconate inhibits glycolysis and oxidative burst, which survival bacterial killing. In murine pneumonia model, Irg1 expression protects lung from excessive inflammation but compromises thus able to innate response targeting metabolism inducing