Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans

• DOI: 10.1016/j.celrep.2023.113131
• Publication Date: 2023-09-13T11:03:55Z
• Authors: Mueez U-Din; Vanessa D. de Mello; Marjo Tuomainen; Juho Raiko; Tarja Niemi; Tobias Fromme; Anton Klåvus; Nadine Gautier; Kimmo Haimilahti; Marko Lehtonen; Karsten Kristiansen; John W. Newman; Kirsi H. Pietiläinen; Jussi Pihlajamäki; Ez-Zoubir Amri; Martin Klingenspor; Pirjo Nuutila; Eija Pirinen; Kati Hanhineva; Kirsi A. Virtanen
• Keywords: Kynurenine pathway; Metabolic pathway

Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during in human BAT exists. We show that serum metabolites salvage pathway (nicotinamide and 1-methylnicotinamide) humans. Additionally, individuals with cold-stimulated have decreased levels from de novo biosynthesis (tryptophan, kynurenine). Serum correlates positively activation, whereas tryptophan kynurenine correlate negatively. Furthermore, expression genes involved related markers Our data indicate conversion be further utilized by BAT. conclude activated upon humans probably regulated a coordinated fashion several tissues.