Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing

• DOI: 10.1016/j.celrep.2024.113844
• Publication Date: 2024-02-27T23:20:10Z
• Authors: Sneha Ray; Pralaksha Gurung; R. Sean Manning; Alexandra A. Krav...; Aakanksha Singhvi
• Keywords: Lipid microdomain

Glia interact with multiple neurons, but it is unclear whether their interactions each neuron are different. Our interrogation at single-cell resolution reveals that a single glial cell exhibits specificity in its different contacting neurons. Briefly, C. elegans amphid sheath (AMsh) glia apical-like domains contact 12 neuron-endings. At these ad-neuronal membranes, AMsh localize the K/Cl transporter KCC-3 to microdomain exclusively around thermosensory AFD regulate properties. Glial transported regions, where distal cilia of non-AFD glia-associated chemosensory neurons constrain AFD-contacting membranes. Aberrant localization impacts both (AFD) and (non-AFD) Thus, can non-synaptically through shared by regulating cues. As across species compartmentalize cues like KCC-3, we posit this may be broadly conserved mechanism modulates information processing multimodal circuits.