Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation

• DOI: 10.1016/j.celrep.2024.113866
• Publication Date: 2024-02-27T23:20:16Z
• Authors: Harry Warner; Giulia Franciosa; Guus van der Borg; Britt Coenen; Felix Faas; Claire Koenig; Rinse de Boer; René Classens; Sjors Maassen; Maksim V. Baranov; Shweta Mahajan; Deepti Dabral; Frans Bianchi; Niek van Hilten; Herre Jelger Riss...; Wouter H. Roos; Jesper Velgaard O...; Laia Querol Cano; Geert van den Bog...
• Keywords: Cofilin

To mount an adaptive immune response, dendritic cells must migrate to lymph nodes present antigens T cells. Critical 3D migration is the nucleus, which size-limiting barrier for through extracellular matrix. Here, we show that inflammatory activation of leads nucleus becoming spherically deformed and enables overcome typical 2- 3-μm diameter limit gaps in We nuclear shape change partially attained reduced cell adhesion, whereas improved achieved reprogramming actin cytoskeleton. Specifically, our data point a model whereby phosphorylation cofilin-1 at serine 41 drives assembly cofilin-actomyosin ring proximal enhances collagen gels. In summary, these describe signaling events deform their enhance migratory capacity.