Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity

• DOI: 10.1016/j.celrep.2024.113932
• Publication Date: 2024-03-07T09:54:16Z
• Authors: Jéssica Cristina ...; María Moreno; Lisa U. Teufel; Sofía Chilibroste; Samuel T. Keating; Laszlo Groh; Jorge Domínguez-A...; David L. Williams; Zuchao Ma; Douglas W. Lowman; Harry E. Ensley; Boris Novakovic; Fátima Ribeiro-Dias; Mihai G. Netea; José A. Chabalgoity; Leo A.B. Joosten
• Keywords: Leishmania braziliensis; Monocyte

Innate immune cells can undergo long-term functional reprogramming after certain infections, a process called trained immunity (TI). Here, we focus on antigens of Leishmania braziliensis, which induced anti-tumor effects via in human monocytes. We reveal that monocytes exposed to promastigote L. braziliensis develop an enhanced response subsequent exposure Toll-like receptor (TLR)2 or TLR4 ligands. Mechanistically, the induction TI by is mediated multiple pattern recognition receptors, changes metabolism, and increased deposition H3K4me3 at promoter regions genes. The administration exerts potent capabilities delaying tumor growth prolonging survival mice with non-Hodgkin lymphoma. Our work reveals mechanisms vitro identifies its potential for cancer immunotherapy.