Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

• DOI: 10.1016/j.celrep.2024.113934
• Publication Date: 2024-03-08T22:06:10Z
• Authors: Yi Luan; Jiajia Hu; Qijun Wang; Xujun Wang; Wenxue Li; Rihao Qu; Chuan Yang; Barani Kumar Raje...; Hongyue Zhou; Peng Liu; Ningning Zhang; Yu Shi; Yansheng Liu; Wenwen Tang; Jun Lu; Dianqing Wu
• Keywords: Myelopoiesis

Neutrophils are important innate immune cells with plasticity, heterogenicity, and functional ambivalency. While bone marrow is often regarded as the primary source of neutrophil production, roles extramedullary production in regulating plasticity heterogenicity autoimmune diseases remain poorly understood. Here, we report that lack wingless-type MMTV integration site family member 5 (WNT5) unleashes anti-inflammatory protection against colitis mice, accompanied by reduced colonic CD8+ T cell activation enhanced splenic myelopoiesis. In addition, upregulates WNT5 expression stromal cells. The ablation leads to increased hematopoietic niche factors, well elevated numbers neutrophils heightened suppressive capability, part due CD101 attenuated pro-inflammatory activities. Thus, our study reveals a mechanism which regulated through highlights role shaping inflammatory outcomes.