Dendrite architecture determines mitochondrial distribution patterns in vivo

• DOI: 10.1016/j.celrep.2024.114190
• Publication Date: 2024-05-06T21:15:50Z
• Authors: Eavan J. Donovan; Anamika Agrawal; Nicole Liberman; Jordan I. Kalai; Avi J. Adler; Adam M. Lamper; Hailey Q. Wang; Nicholas J. Chua; Elena F. Koslover; Erin L. Barnhart
• Keywords: Dendrite (mathematics); Organelle

Neuronal morphology influences synaptic connectivity and neuronal signal processing. However, it remains unclear how shape affects steady-state distributions of organelles like mitochondria. In this work, we investigated the link between mitochondrial transport dendrite branching patterns by combining mathematical modeling with in vivo measurements architecture, motility, localization Drosophila HS (horizontal system) neurons. our model, different forms morphological scaling rules—which set relative thicknesses parent daughter branches at each junction dendritic arbor motility to branch thickness—predict dramatically global patterns. We show that dendrites obey specific subset rules that, lead realistic distributions. Moreover, demonstrate activity does not affect or localization, indicating are hard-wired architecture neuron.