Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids

• DOI: 10.1016/j.cgh.2020.02.045
• Publication Date: 2020-02-29T06:46:39Z
• Authors: Joseph F. Lacomb; Dennis Plenker; Hervé Tiriac; Juan Carlos Bucobo; Lionel S. D’souza; Asim S. Khokhar; Hardik Patel; Breana Channer; Dimitri Joseph; Maoxin Wu; David A. Tuveson; Ellen Li; Jonathan M. Busca...
• Keywords: Endoscopic Ultrasound; Organoid; Fine needle biopsy

Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses of all malignancies, with a 5-year survival rate <8%.1,2 Suspicious lesions are typically diagnosed via endoscopic ultrasound-guided fine-needle aspiration or endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB).3 Fewer needle passes decreases the risk of postprocedure complications, including pancreatitis and hemorrhage, while allowing additional needle passes to be used for adjuvant tissue testing, such as organoid creation and DNA sequencing.