Hybrid and Conventional Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multi-Center Randomized Controlled Trial

• DOI: 10.1016/j.cgh.2022.10.030
• Publication Date: 2022-11-05T03:02:16Z
• Authors: Mitsuru Esaki; Eikichi Ihara; Yorinobu Sumida; Hiroyuki Fujii; Shunsuke Takahashi; Kazuhiro Haraguchi; Tsutomu Iwasa; Shinichi Somada; Yosuke Minoda; Haruei Ogino; Koshiro Tagawa; Yoshihiro Ogawa
• Keywords: Endoscopic submucosal dissection; Single Center; Endoscopic mucosal resection

Hybrid endoscopic submucosal dissection (H-ESD), which incorporates (ESD) with mucosal resection, has been developed to make ESD technically easier. This study aimed determine if H-ESD is superior conventional (C-ESD) for small early gastric neoplasms (EGNs).We conducted a multi-center, prospective, open-label, randomized controlled trial compare the treatment outcomes of and C-ESD (Hybrid-G Trial). Patients differentiated type intramucosal EGN ≤20 mm in diameter without ulceration were randomly assigned (1:1) groups that underwent or C-ESD. A single multi-functional snare, SOUTEN (ST1850-20, Kaneka, Medix, Tokyo, Japan), was used H-ESD. The primary outcome procedure time. Secondary included incision time, time speed dissection, curability, procedural adverse events.A total 39 40 patients C-ESD, respectively. significantly shorter than (33.16 min vs 62.46 min; H-ESD/C-ESD ratio: 0.53; 95% confidence interval, 0.41-0.69; P < .0001). There no significant difference between 2 groups; those No observed other outcomes.H-ESD high comparable curability safety both can be good option EGNs. (UMIN Clinical Trials Registry, Numbers: UMIN000041244).